- Main article: Riley Matthews
Riley Matthews is the twelve year old daughter of Cory and Topanga, and the older sister of Auggie. She is the oldest child of the Matthews family, while her brother Auggie is the youngest. Her father is also her seventh grade history teacher. Riley's best friends are Maya Hart and Farkle Minkus. Riley is portrayed by Rowan Blanchard. By the end of the series, she is fifteen and her father is her history teacher in high school.
- Main article: Cory Matthews
Cornelius A. "Cory" Matthews is Riley's father and the lead character of Boy Meets World. Cory has taken a job as a middle-school history teacher, whose class will consist of his daughter and many of her friends. Cory is portrayed by Ben Savage.
- Main article: Maya Hart
Maya Hart is Riley Matthews' best friend. Maya isn't one of the best students in school, yet she still looks up to Cory Matthews as a father figure, having never met her actual father. However, she is deeply loyal to Riley, as Riley is to her. Maya lives with her mother. Not only is Maya a slacker in school, she, like Shawn, also has an absentee parent. Maya is portrayed by Sabrina Carpenter.
- Main article: Lucas Friar
Lucas Friar is a native of Austin, Texas, and is a "cowboy in the city." He is possibly a love interest of Riley Matthews, who wants to be his friend, even though she believes he is too good looking for her. Lucas is portrayed by Peyton Meyer.
- Main article: Farkle Minkus
Farkle Minkus is a genius and nerd, and finds Maya Hart to be his nemesis, but Maya's best friend, Riley Matthews, always intervenes to save his life. Farkle is attached to and protective of both girls, and loves them equally. He is the son of Stuart Minkus. Farkle is portrayed by Corey Fogelmanis.
- Main article: Auggie Matthews
Auggie Matthews is Riley's five-year-old little brother and Cory and Topanga's youngest son. Auggie is portrayed by August Maturo.
- Main article: Topanga Matthews
Topanga Matthews is Riley's mother. She works at a New York City law firm, where she has been employed since accepting a position as an intern in the finale of Boy Meets World. Topanga is portrayed by Danielle Fishel
- Main article: Zay Babineaux
Zay is Lucas' long childhood friend who moved to be closer to him. Zay is portrayed by Amir Mitchell-Townes.
- Main article: Isadora Smackle
Isadora Smackle is Farkle's former academic rival and current girlfriend. She is portrayed by Cecilia Balagot.
- Main article: Shawn Hunter
- Main article: Ava Morgenstern
Ava is Auggie's "girlfriend." She is slightly bossy. Ava is portrayed by Ava Kolker.
- Main article: George Feeny
- Main article: Stuart Minkus
Stuart Minkus was one of Cory's classmates in sixth grade. Shawn and Cory tended to bully Minkus in Boy Meets World. He was the top of his graduating class. He is also the father of Farkle Minkus. Minkus is portrayed by Lee Norris.
- Main article: Harley Keiner
- Main article: Alan Matthews
- Main article: Amy Matthews
- Main article: Dweezil
Dweezil is the man who played drums in the underground and Maya grooved to the drum beats. He appeared in "Girl Meets World." Dweezil is portrayed by Kurt Collins.
- Main article: Evelyn Rand
Evelyn Rand is the lady who just had worked a twelve-hour shift and asked if Riley perhaps would give her seat up to someone else. She appeared in "Girl Meets World." Evelyn is portrayed by Jackée Harry.